Indian-origin scientist helps restore youthful flexibility to old brains

Published on May 23, 2015 12:35:35 PM

A group of researchers in New York, including one of an Indian-origin, have devised a method to restore youthful flexibility in old brains, accordingly preparing to new medications for developmental brain disorders like Autism and Schizophrenia.

Neurobiologist Sunil Gandhi and associates from University of California-Irvine successfully re-made a critical juvenile period in the brains of adult mice and in the process they remedied a sight issue with which the mice were afflicted.

The researchers brought up that much like older muscles lose their youthful flexibility, older brains lose their versatility - the fast and vigorous changes in brain connections as a consequence of learning and experience.

However, in the new study, the transplanted brain cells created another period of heightened versatility that took into consideration vigorous rewiring of the adult brain. In simpler terms, old mind procedures became youthful once more.

The researchers accomplished this by transplanting a certain kind of embryonic neuron into the brains of the adult mice. The transplanted neurons express gamma amino butyric acid (GABA) cells that guide in motor control, vision and numerous other cortical capabilities.

For the study, trying to restore normal sight, the specialists’ transplanted GABA neurons into the visual cortex of the adult mice harrowed with a sight-issue.

"Several weeks after transplantation, when the donor animal's visual system would be going through its critical period, the amblyopic mice started to see with normal visual acuity," lead author of the study, Melissa Davis, stated.